Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubs-tituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists

A series of chiral pyridazin-3(2H)-ones was synthesized, separated as pure enantiomers, and evaluated for N-formyl peptide receptor (FPR) agonist activity. Characterization of the purified enantiomers using combined chiral HPLC and chiroptical studies (circular dichroism, allowed unambiguous assignm...

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Detalhes bibliográficos
Main Authors: Cilibrizzi, Agostino, Schepetkin, Igor A., Bartolucci, Gianluca, Crocetti, Letizia, Piaz, Vittorio Dal, Giovannoni, Maria Paola, Graziano, Alessia, Kirpotina, Liliya N., Quinn, Mark T., Vergelli, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565387/
https://ncbi.nlm.nih.gov/pubmed/22607879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.04.043
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