Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase

Human neutrophil elastase (HNE) plays an important role in tumour invasion and inflammation. A series of N-benzoylindazoles was synthesized and evaluated for their ability to inhibit HNE. We found that this scaffold is appropriate for HNE inhibitors and that the benzoyl fragment at position 1 is ess...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Crocetti, Letizia, Giovannoni, Maria Paola, Schepetkin, Igor A., Quinn, Mark T., Khlebnikov, Andrei I., Cilibrizzi, Agostino, Piaz, Vittorio Dal, Graziano, Alessia, Vergelli, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777343/
https://ncbi.nlm.nih.gov/pubmed/21741848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.06.036
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