Optimization of N-benzoylindazole Derivatives as Inhibitors of Human Neutrophil Elastase

Human neutrophil elastase (HNE) is an important therapeutic target for treatment of pulmonary diseases. Previously, we identified novel N-benzoylindazole derivatives as potent, competitive, and pseudoirreversible HNE inhibitors. Here, we report further development of these inhibitors with improved p...

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Autores principales: Crocetti, Letizia, Schepetkin, Igor A., Cilibrizzi, Agostino, Graziano, Alessia, Vergelli, Claudia, Giomi, Donatella, Khlebnikov, Andrei I., Quinn, Mark T., Giovannoni, Maria Paola
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807862/
https://ncbi.nlm.nih.gov/pubmed/23844670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400742j
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