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Optimization of N-benzoylindazole Derivatives as Inhibitors of Human Neutrophil Elastase
Human neutrophil elastase (HNE) is an important therapeutic target for treatment of pulmonary diseases. Previously, we identified novel N-benzoylindazole derivatives as potent, competitive, and pseudoirreversible HNE inhibitors. Here, we report further development of these inhibitors with improved p...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3807862/ https://ncbi.nlm.nih.gov/pubmed/23844670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400742j |
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