Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors

Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HNE proteolytic activity could represent effective therapeutics. We present here the synthesi...

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Veröffentlicht in:Chem Cent J
Hauptverfasser: Crocetti, Letizia, Bartolucci, Gianluca, Cilibrizzi, Agostino, Giovannoni, Maria Paola, Guerrini, Gabriella, Iacovone, Antonella, Menicatti, Marta, Schepetkin, Igor A., Khlebnikov, Andrei I., Quinn, Mark T., Vergelli, Claudia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718994/
https://ncbi.nlm.nih.gov/pubmed/29214393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-017-0358-1
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