Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors

Human neutrophil elastase (HNE) is an important target for the development of novel and selective inhibitors to treat inflammatory diseases, especially pulmonary pathologies. Here, we report the synthesis, structure–activity relationship analysis, and biological evaluation of a new series of HNE inh...

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Détails bibliographiques
Publié dans:J Enzyme Inhib Med Chem
Auteurs principaux: Vergelli, Claudia, Schepetkin, Igor A., Crocetti, Letizia, Iacovone, Antonella, Giovannoni, Maria Paola, Guerrini, Gabriella, Khlebnikov, Andrei I., Ciattini, Samuele, Ciciani, Giovanna, Quinn, Mark T.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2017
Sujets:
Reasearch Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927774/
https://ncbi.nlm.nih.gov/pubmed/28612630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1326915
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