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Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors

Human neutrophil elastase (HNE) is an important target for the development of novel and selective inhibitors to treat inflammatory diseases, especially pulmonary pathologies. Here, we report the synthesis, structure–activity relationship analysis, and biological evaluation of a new series of HNE inh...

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Bibliografski detalji
Izdano u:J Enzyme Inhib Med Chem
Glavni autori: Vergelli, Claudia, Schepetkin, Igor A., Crocetti, Letizia, Iacovone, Antonella, Giovannoni, Maria Paola, Guerrini, Gabriella, Khlebnikov, Andrei I., Ciattini, Samuele, Ciciani, Giovanna, Quinn, Mark T.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2017
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927774/
https://ncbi.nlm.nih.gov/pubmed/28612630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1326915
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