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Cinnoline derivatives as human neutrophil elastase inhibitors
Compounds that can effectively inhibit the proteolytic activity of human neutrophil elastase (HNE) represent promising therapeutics for treatment of inflammatory diseases. We present here the synthesis, structure–activity relationship analysis, and biological evaluation of a new series of HNE inhibi...
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| Publicado no: | J Enzyme Inhib Med Chem |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4721940/ https://ncbi.nlm.nih.gov/pubmed/26194018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/14756366.2015.1057718 |
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