CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an essential regulator of T-cell responses, and its absence precipitates lethal T-cell hyperactivity. However, whether CTLA-4 acts simply to veto the activation of certain clones or plays a more nuanced role in shaping the quality of T-cell res...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Wang, Chun Jing, Heuts, Frank, Ovcinnikovs, Vitalijs, Wardzinski, Lukasz, Bowers, Chantelle, Schmidt, Emily M., Kogimtzis, Alexandros, Kenefeck, Rupert, Sansom, David M., Walker, Lucy S. K.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299196/
https://ncbi.nlm.nih.gov/pubmed/25548162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414576112
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