Superior inhibition of alloantibody responses with selective CD28 blockade is CTLA-4-dependent and T follicular helper cell-specific

Anti-donor antibodies cause immunologic injury in transplantation. CD28 blockade with CTLA-4-Ig has the ability to reduce the incidence of these donor-specific antibodies (DSA), but its mechanism is suboptimal for the inhibition of alloimmunity in that CTLA-4-Ig blocks both CD28 costimulation and CT...

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Bibliographic Details
Published in:Am J Transplant
Main Authors: La Muraglia, G. Michael, Zeng, Susan, Crichton, Emma S., Wagener, Maylene E., Ford, Mandy L., Badell, I. Raul
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7665991/
https://ncbi.nlm.nih.gov/pubmed/32406182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.16004
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