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Superior inhibition of alloantibody responses with selective CD28 blockade is CTLA-4-dependent and T follicular helper cell-specific
Anti-donor antibodies cause immunologic injury in transplantation. CD28 blockade with CTLA-4-Ig has the ability to reduce the incidence of these donor-specific antibodies (DSA), but its mechanism is suboptimal for the inhibition of alloimmunity in that CTLA-4-Ig blocks both CD28 costimulation and CT...
Gardado en:
| Publicado en: | Am J Transplant |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7665991/ https://ncbi.nlm.nih.gov/pubmed/32406182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.16004 |
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