Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood–brain barrier function in mice

Human apolipoprotein E (APOE) exists in three isoforms ɛ2, ɛ3, and ɛ4, of which APOE4 is the main genetic risk factor of Alzheimer's disease (AD). As cerebrovascular defects are associated with AD, we tested whether APOE genotype has an impact on the integrity and function of the blood–brain ba...

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Bibliografske podrobnosti
izdano v:J Cereb Blood Flow Metab
Main Authors: Alata, Wael, Ye, Yue, St-Amour, Isabelle, Vandal, Milène, Calon, Frédéric
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296574/
https://ncbi.nlm.nih.gov/pubmed/25335802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.172
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