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Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood–brain barrier function in mice
Human apolipoprotein E (APOE) exists in three isoforms ɛ2, ɛ3, and ɛ4, of which APOE4 is the main genetic risk factor of Alzheimer's disease (AD). As cerebrovascular defects are associated with AD, we tested whether APOE genotype has an impact on the integrity and function of the blood–brain ba...
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| Publicat a: | J Cereb Blood Flow Metab |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4296574/ https://ncbi.nlm.nih.gov/pubmed/25335802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.172 |
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