Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood–brain barrier function in mice

Human apolipoprotein E (APOE) exists in three isoforms ɛ2, ɛ3, and ɛ4, of which APOE4 is the main genetic risk factor of Alzheimer's disease (AD). As cerebrovascular defects are associated with AD, we tested whether APOE genotype has an impact on the integrity and function of the blood–brain ba...

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Bibliographic Details
Published in:J Cereb Blood Flow Metab
Main Authors: Alata, Wael, Ye, Yue, St-Amour, Isabelle, Vandal, Milène, Calon, Frédéric
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296574/
https://ncbi.nlm.nih.gov/pubmed/25335802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.172
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