Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria

Several progeroid disorders, including Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (ZMPSTE24 deficiency), arise when a farnesylated and methylated form of prelamin A accumulates at the nuclear envelope. Here, we found that a hypomorphic allele of isoprenylcysteine carboxyl...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Science
Egile Nagusiak: Ibrahim, Mohamed X., Sayin, Volkan I., Akula, Murali K., Liu, Meng, Fong, Loren G., Young, Stephen G., Bergo, Martin O.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295631/
https://ncbi.nlm.nih.gov/pubmed/23686339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1238880
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak