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Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria
Several progeroid disorders, including Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (ZMPSTE24 deficiency), arise when a farnesylated and methylated form of prelamin A accumulates at the nuclear envelope. Here, we found that a hypomorphic allele of isoprenylcysteine carboxyl...
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| Veröffentlicht in: | Science |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4295631/ https://ncbi.nlm.nih.gov/pubmed/23686339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1238880 |
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