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Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria

Several progeroid disorders, including Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (ZMPSTE24 deficiency), arise when a farnesylated and methylated form of prelamin A accumulates at the nuclear envelope. Here, we found that a hypomorphic allele of isoprenylcysteine carboxyl...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Ibrahim, Mohamed X., Sayin, Volkan I., Akula, Murali K., Liu, Meng, Fong, Loren G., Young, Stephen G., Bergo, Martin O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295631/
https://ncbi.nlm.nih.gov/pubmed/23686339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1238880
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