Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance

Most human cancers depend on the telomerase to maintain telomeres; however, about 10% of cancers are telomerase negative and utilize the alternative lengthening of telomeres (ALT) mechanism. Mutations in the DAXX gene have been found frequently in both telomerase-positive and ALT cells, and how DAXX...

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Udgivet i:J Cell Sci
Main Authors: Tang, Mengfan, Li, Yujing, Zhang, Yi, Chen, Yuxi, Huang, Wenjun, Wang, Dan, Zaug, Arthur J., Liu, Dan, Zhao, Yong, Cech, Thomas R., Ma, Wenbin, Songyang, Zhou
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294776/
https://ncbi.nlm.nih.gov/pubmed/25416818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.159467
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