Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX

Activation of telomerase or alternative lengthening of telomeres (ALT) is necessary for tumours to escape from dysfunctional telomere-mediated senescence. Anti-telomerase drugs might be effective in suppressing tumour growth in approximately 85–90% of telomerase-positive cancer cells. However, there...

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Vydáno v:Sci Rep
Hlavní autoři: Hu, Yang, Shi, Guang, Zhang, Laichen, Li, Feng, Jiang, Yuanling, Jiang, Shuai, Ma, Wenbin, Zhao, Yong, Songyang, Zhou, Huang, Junjiu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006076/
https://ncbi.nlm.nih.gov/pubmed/27578458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32280
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