Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX

Activation of telomerase or alternative lengthening of telomeres (ALT) is necessary for tumours to escape from dysfunctional telomere-mediated senescence. Anti-telomerase drugs might be effective in suppressing tumour growth in approximately 85–90% of telomerase-positive cancer cells. However, there...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hu, Yang, Shi, Guang, Zhang, Laichen, Li, Feng, Jiang, Yuanling, Jiang, Shuai, Ma, Wenbin, Zhao, Yong, Songyang, Zhou, Huang, Junjiu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006076/
https://ncbi.nlm.nih.gov/pubmed/27578458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32280
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