Interleukin-1 Receptor-associated Kinase-4 (IRAK4) Promotes Inflammatory Osteolysis by Activating Osteoclasts and Inhibiting Formation of Foreign Body Giant Cells

Formation of foreign body giant cells (FBGCs) occurs following implantation of medical devices such as artificial joints and is implicated in implant failure associated with inflammation or microbial infection. Two major macrophage subpopulations, M1 and M2, play different roles in inflammation and...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Katsuyama, Eri, Miyamoto, Hiroya, Kobayashi, Tami, Sato, Yuiko, Hao, Wu, Kanagawa, Hiroya, Fujie, Atsuhiro, Tando, Toshimi, Watanabe, Ryuichi, Morita, Mayu, Miyamoto, Kana, Niki, Yasuo, Morioka, Hideo, Matsumoto, Morio, Toyama, Yoshiaki, Miyamoto, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294496/
https://ncbi.nlm.nih.gov/pubmed/25404736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568360
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