Interleukin-1 Receptor-associated Kinase-4 (IRAK4) Promotes Inflammatory Osteolysis by Activating Osteoclasts and Inhibiting Formation of Foreign Body Giant Cells

Formation of foreign body giant cells (FBGCs) occurs following implantation of medical devices such as artificial joints and is implicated in implant failure associated with inflammation or microbial infection. Two major macrophage subpopulations, M1 and M2, play different roles in inflammation and...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Katsuyama, Eri, Miyamoto, Hiroya, Kobayashi, Tami, Sato, Yuiko, Hao, Wu, Kanagawa, Hiroya, Fujie, Atsuhiro, Tando, Toshimi, Watanabe, Ryuichi, Morita, Mayu, Miyamoto, Kana, Niki, Yasuo, Morioka, Hideo, Matsumoto, Morio, Toyama, Yoshiaki, Miyamoto, Takeshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294496/
https://ncbi.nlm.nih.gov/pubmed/25404736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568360
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