The Vitamin D Analogue ED71 but Not 1,25(OH)(2)D(3) Targets HIF1α Protein in Osteoclasts

Although both an active form of the vitamin D metabolite, 1,25(OH)(2)D(3), and the vitamin D analogue, ED71 have been used to treat osteoporosis, anti-bone resorbing activity is reportedly seen only in ED71- but not in 1,25(OH)(2)D(3) -treated patients. In addition, how ED71 inhibits osteoclast acti...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sato, Yuiko, Miyauchi, Yoshiteru, Yoshida, Shigeyuki, Morita, Mayu, Kobayashi, Tami, Kanagawa, Hiroya, Katsuyama, Eri, Fujie, Atsuhiro, Hao, Wu, Tando, Toshimi, Watanabe, Ryuichi, Miyamoto, Kana, Morioka, Hideo, Matsumoto, Morio, Toyama, Yoshiaki, Miyamoto, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222951/
https://ncbi.nlm.nih.gov/pubmed/25375896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111845
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