CXCL12/CXCR4 signaling counteracts docetaxel-induced microtubule stabilization via p21-activated kinase 4-dependent activation of LIM domain kinase 1

Emerging data highlight the significance of chemokine (C-X-C motif) ligand 12/chemokine (C-X-C motif) receptor 4 (CXCL12/CXCR4) signaling axis in the chemoresistance of several malignancies, including prostate cancer (PCa); however, underlying mechanisms remain largely elusive. Here, we demonstrate...

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Publicado en:Oncotarget
Autores principales: Bhardwaj, Arun, Srivastava, Sanjeev K., Singh, Seema, Arora, Sumit, Tyagi, Nikhil, Andrews, Joel, McClellan, Steven, Carter, James E., Singh, Ajay P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294337/
https://ncbi.nlm.nih.gov/pubmed/25359780
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