CXCL12/CXCR4 Protein Signaling Axis Induces Sonic Hedgehog Expression in Pancreatic Cancer Cells via Extracellular Regulated Kinase- and Akt Kinase-mediated Activation of Nuclear Factor κB: IMPLICATIONS FOR BIDIRECTIONAL TUMOR-STROMAL INTERACTIONS

Recent evidence suggests a major role of tumor-stromal interactions in pancreatic cancer pathobiology. The chemokine CXCL12 (stromal cell-derived factor 1 (SDF-1)), abundantly produced by stromal cells, promotes progression, metastasis, and chemoresistance of pancreatic cancer cells. On the other ha...

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Main Authors: Singh, Ajay P., Arora, Sumit, Bhardwaj, Arun, Srivastava, Sanjeev K., Kadakia, Madhavi P., Wang, Bin, Grizzle, William E., Owen, Laurie B., Singh, Seema
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493952/
https://ncbi.nlm.nih.gov/pubmed/22995914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.409581
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