An Undesired Effect of Chemotherapy: GEMCITABINE PROMOTES PANCREATIC CANCER CELL INVASIVENESS THROUGH REACTIVE OXYGEN SPECIES-DEPENDENT, NUCLEAR FACTOR κB- AND HYPOXIA-INDUCIBLE FACTOR 1α-MEDIATED UP-REGULATION OF CXCR4

Recently, we have shown that CXCL12/CXCR4 signaling plays an important role in gemcitabine resistance of pancreatic cancer (PC) cells. Here, we explored the effect of gemcitabine on this resistance mechanism. Our data demonstrate that gemcitabine induces CXCR4 expression in two PC cell lines (MiaPaC...

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Detalhes bibliográficos
Main Authors: Arora, Sumit, Bhardwaj, Arun, Singh, Seema, Srivastava, Sanjeev K., McClellan, Steven, Nirodi, Chaitanya S., Piazza, Gary A., Grizzle, William E., Owen, Laurie B., Singh, Ajay P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774385/
https://ncbi.nlm.nih.gov/pubmed/23740244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484576
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