An Undesired Effect of Chemotherapy: GEMCITABINE PROMOTES PANCREATIC CANCER CELL INVASIVENESS THROUGH REACTIVE OXYGEN SPECIES-DEPENDENT, NUCLEAR FACTOR κB- AND HYPOXIA-INDUCIBLE FACTOR 1α-MEDIATED UP-REGULATION OF CXCR4

Recently, we have shown that CXCL12/CXCR4 signaling plays an important role in gemcitabine resistance of pancreatic cancer (PC) cells. Here, we explored the effect of gemcitabine on this resistance mechanism. Our data demonstrate that gemcitabine induces CXCR4 expression in two PC cell lines (MiaPaC...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Arora, Sumit, Bhardwaj, Arun, Singh, Seema, Srivastava, Sanjeev K., McClellan, Steven, Nirodi, Chaitanya S., Piazza, Gary A., Grizzle, William E., Owen, Laurie B., Singh, Ajay P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Molecular Bases of Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774385/
https://ncbi.nlm.nih.gov/pubmed/23740244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484576
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