An Undesired Effect of Chemotherapy: GEMCITABINE PROMOTES PANCREATIC CANCER CELL INVASIVENESS THROUGH REACTIVE OXYGEN SPECIES-DEPENDENT, NUCLEAR FACTOR κB- AND HYPOXIA-INDUCIBLE FACTOR 1α-MEDIATED UP-REGULATION OF CXCR4

Recently, we have shown that CXCL12/CXCR4 signaling plays an important role in gemcitabine resistance of pancreatic cancer (PC) cells. Here, we explored the effect of gemcitabine on this resistance mechanism. Our data demonstrate that gemcitabine induces CXCR4 expression in two PC cell lines (MiaPaC...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Arora, Sumit, Bhardwaj, Arun, Singh, Seema, Srivastava, Sanjeev K., McClellan, Steven, Nirodi, Chaitanya S., Piazza, Gary A., Grizzle, William E., Owen, Laurie B., Singh, Ajay P.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2013
الموضوعات:
Molecular Bases of Disease
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774385/
https://ncbi.nlm.nih.gov/pubmed/23740244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484576
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