p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling

Pancreatic cancer (PC) remains a highly lethal malignancy due to its unusual chemoresistance and high aggressiveness. A subpopulation of pancreatic tumor cells, known as cancer stem cells (CSCs), is considered responsible not only for tumor-maintenance, but also for its widespread metastasis and the...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Tyagi, Nikhil, Marimuthu, Saravanakumar, Bhardwaj, Arun, Deshmukh, Sachin K., Srivastava, Sanjeev K., Singh, Ajay P., McClellan, Steven, Carter, James E., Singh, Seema
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684758/
https://ncbi.nlm.nih.gov/pubmed/26546043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.10.028
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