MicroRNA-345 induces apoptosis in pancreatic cancer cells through potentiation of caspase-dependent and -independent pathways

BACKGROUND: Previously, miR-345 was identified as one of the most significantly downregulated microRNAs in pancreatic cancer (PC); however, its functional significance remained unexplored. METHODS: miR-345 was overexpressed in PC cells by stable transfection, and its effect on growth, apoptosis and...

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Vydáno v:Br J Cancer
Hlavní autoři: Srivastava, Sanjeev K, Bhardwaj, Arun, Arora, Sumit, Tyagi, Nikhil, Singh, Seema, Andrews, Joel, McClellan, Steve, Wang, Bin, Singh, Ajay P
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647684/
https://ncbi.nlm.nih.gov/pubmed/26247574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.252
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