Prostate cancer cells hyper-activate CXCR6 signaling by cleaving CXCL16 to overcome effect of docetaxel

Molecular reprogramming in response to chemotherapeutics leads to poor therapeutic outcomes for prostate cancer (PCa). In this study, we demonstrated that CXCR6-CXCL16 axis promotes DTX resistance and acts as a counter-defense mechanism. After CXCR6 activation, cell death in response to DTX was inhi...

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Gepubliceerd in:Cancer Lett
Hoofdauteurs: Kapur, Neeraj, Mir, Hina, Sonpavde, Guru, Jain, Sanjay, Bae, Sejong, Lillard, James W., Singh, Shailesh
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7748218/
https://ncbi.nlm.nih.gov/pubmed/30974114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.04.001
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