Prostate cancer cells hyper-activate CXCR6 signaling by cleaving CXCL16 to overcome effect of docetaxel

Molecular reprogramming in response to chemotherapeutics leads to poor therapeutic outcomes for prostate cancer (PCa). In this study, we demonstrated that CXCR6-CXCL16 axis promotes DTX resistance and acts as a counter-defense mechanism. After CXCR6 activation, cell death in response to DTX was inhi...

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Опубликовано в: :Cancer Lett
Главные авторы: Kapur, Neeraj, Mir, Hina, Sonpavde, Guru, Jain, Sanjay, Bae, Sejong, Lillard, James W., Singh, Shailesh
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7748218/
https://ncbi.nlm.nih.gov/pubmed/30974114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.04.001
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