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Mechanistic Studies of the Radical SAM Enzyme DesII with TDP-d-Fucose
DesII is a radical SAM enzyme that catalyzes the C4-deamination of TDP-4-amino-4,6-dideoxyglucose via a C3 radical intermediate. However, if the C4 amino group is replaced with a hydroxyl (TDP-quinovose), the hydroxyl at C3 is oxidized to a ketone with no C4-dehydration. It is hypothesized that hype...
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| Udgivet i: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4293265/ https://ncbi.nlm.nih.gov/pubmed/25418063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201409540 |
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