Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

In Alzheimer disease, the microtubule-associated protein tau dissociates from the neuronal cytoskeleton and aggregates to form cytoplasmic inclusions. Although hyper-phosphorylation of tau Ser and Thr residues is an established trigger of tau misfunction and aggregation, tau modifications extend to...

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Veröffentlicht in:Biochem J
Hauptverfasser: Funk, Kristen E., Thomas, Stefani N., Schafer, Kelsey N., Cooper, Grace L., Liao, Zhongping, Clark, David J., Yang, Austin J., Kuret, Jeff
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292886/
https://ncbi.nlm.nih.gov/pubmed/24869773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140372
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