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Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity
In Alzheimer disease, the microtubule-associated protein tau dissociates from the neuronal cytoskeleton and aggregates to form cytoplasmic inclusions. Although hyper-phosphorylation of tau Ser and Thr residues is an established trigger of tau misfunction and aggregation, tau modifications extend to...
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| Udgivet i: | Biochem J |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292886/ https://ncbi.nlm.nih.gov/pubmed/24869773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140372 |
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