Rapid modeling of cooperating genetic events in cancer through somatic genome editing

Cancer is a multistep process that involves mutations and other alterations in oncogenes and tumor suppressor genes(1). Genome sequencing studies have identified a large collection of genetic alterations that occur in human cancers(2–4). However, the determination of which mutations are causally rel...

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Udgivet i:Nature
Main Authors: Sánchez-Rivera, Francisco J., Papagiannakopoulos, Thales, Romero, Rodrigo, Tammela, Tuomas, Bauer, Matthew R., Bhutkar, Arjun, Joshi, Nikhil S., Subbaraj, Lakshmipriya, Bronson, Roderick T., Xue, Wen, Jacks, Tyler
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292871/
https://ncbi.nlm.nih.gov/pubmed/25337879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13906
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