Contribution of Clinically Derived Mutations in ERG11 to Azole Resistance in Candida albicans

In Candida albicans, the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in resistance. Although ERG11 mutations have been observed i...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Flowers, Stephanie A., Colón, Brendan, Whaley, Sarah G., Schuler, Mary A., Rogers, P. David
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291385/
https://ncbi.nlm.nih.gov/pubmed/25385095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03470-14
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