Contribution of Clinically Derived Mutations in ERG11 to Azole Resistance in Candida albicans

In Candida albicans, the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in resistance. Although ERG11 mutations have been observed i...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Flowers, Stephanie A., Colón, Brendan, Whaley, Sarah G., Schuler, Mary A., Rogers, P. David
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291385/
https://ncbi.nlm.nih.gov/pubmed/25385095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03470-14
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker