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Contribution of Clinically Derived Mutations in ERG11 to Azole Resistance in Candida albicans
In Candida albicans, the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in resistance. Although ERG11 mutations have been observed i...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Antimicrob Agents Chemother |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Microbiology
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291385/ https://ncbi.nlm.nih.gov/pubmed/25385095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03470-14 |
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