Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

In Candida albicans, Upc2 is a zinc-cluster transcription factor that targets genes, including those of the ergosterol biosynthesis pathway. To date, three documented UPC2 gain-of-function (GOF) mutations have been recovered from fluconazole-resistant clinical isolates that contribute to an increase...

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Bibliografiset tiedot
Päätekijät: Flowers, Stephanie A., Barker, Katherine S., Berkow, Elizabeth L., Toner, Geoffrey, Chadwick, Sean G., Gygax, Scott E., Morschhäuser, Joachim, Rogers, P. David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2012
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485914/
https://ncbi.nlm.nih.gov/pubmed/22923048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00215-12
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