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An A643T Mutation in the Transcription Factor Upc2p Causes Constitutive ERG11 Upregulation and Increased Fluconazole Resistance in Candida albicans

The zinc cluster transcription factor Upc2p mediates upregulation of ergosterol biosynthesis genes in response to ergosterol depletion in the fungal pathogen Candida albicans. One mechanism of acquired resistance to the antifungal drug fluconazole, which inhibits ergosterol biosynthesis, is constitu...

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Main Authors: Heilmann, Clemens J., Schneider, Sabrina, Barker, Katherine S., Rogers, P. David, Morschhäuser, Joachim
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798556/
https://ncbi.nlm.nih.gov/pubmed/19884367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01102-09
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