Competitive Fitness of Fluconazole-Resistant Clinical Candida albicans Strains

The pathogenic yeast Candida albicans can develop resistance to the widely used antifungal agent fluconazole, which inhibits ergosterol biosynthesis. Resistance is often caused by gain-of-function mutations in the transcription factors Mrr1 and Tac1, which result in constitutive overexpression of mu...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Popp, Christina, Hampe, Irene A. I., Hertlein, Tobias, Ohlsen, Knut, Rogers, P. David, Morschhäuser, Joachim
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487674/
https://ncbi.nlm.nih.gov/pubmed/28461316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00584-17
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