Competitive Fitness of Fluconazole-Resistant Clinical Candida albicans Strains

The pathogenic yeast Candida albicans can develop resistance to the widely used antifungal agent fluconazole, which inhibits ergosterol biosynthesis. Resistance is often caused by gain-of-function mutations in the transcription factors Mrr1 and Tac1, which result in constitutive overexpression of mu...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Popp, Christina, Hampe, Irene A. I., Hertlein, Tobias, Ohlsen, Knut, Rogers, P. David, Morschhäuser, Joachim
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487674/
https://ncbi.nlm.nih.gov/pubmed/28461316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00584-17
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items