Regulation of Efflux Pump Expression and Drug Resistance by the Transcription Factors Mrr1, Upc2, and Cap1 in Candida albicans

Constitutive overexpression of the Mdr1 efflux pump is an important mechanism of acquired drug resistance in the yeast Candida albicans. The zinc cluster transcription factor Mrr1 is a central regulator of MDR1 expression, but other transcription factors have also been implicated in MDR1 regulation....

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Autors principals: Schubert, Sabrina, Barker, Katherine S., Znaidi, Sadri, Schneider, Sabrina, Dierolf, Franziska, Dunkel, Nico, Aïd, Malika, Boucher, Geneviève, Rogers, P. David, Raymond, Martine, Morschhäuser, Joachim
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088179/
https://ncbi.nlm.nih.gov/pubmed/21402859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01343-10
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