Differential Requirement of the Transcription Factor Mcm1 for Activation of the Candida albicans Multidrug Efflux Pump MDR1 by Its Regulators Mrr1 and Cap1

Overexpression of the multidrug efflux pump Mdr1 causes increased fluconazole resistance in the pathogenic yeast Candida albicans. The transcription factors Mrr1 and Cap1 mediate MDR1 upregulation in response to inducing stimuli, and gain-of-function mutations in Mrr1 or Cap1, which render the trans...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Mogavero, Selene, Tavanti, Arianna, Senesi, Sonia, Rogers, P. David, Morschhäuser, Joachim
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2011
Ämnen:
Mechanisms of Resistance
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088249/
https://ncbi.nlm.nih.gov/pubmed/21343453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01467-10
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