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Structure activity relationship of cyclic thiacarbocyanine tau aggregation inhibitors
Macrocyclic bis-carbocyanines are efficacious inhibitors of tau aggregation. To extend the structure activity relationship of this inhibitor class, N,N′-alkylene bis-thiacarbocyanines linked by three to nine carbon alkyl chains were synthesized and examined for inhibitory activity against recombinan...
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| Publicat a: | Bioorg Med Chem Lett |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291179/ https://ncbi.nlm.nih.gov/pubmed/21549596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.04.039 |
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