Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles

Allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu(5)) have exciting potential as therapeutic agents for multiple brain disorders. Translational studies with mGlu(5) modulators have relied on mGlu(5) allosteric site positron emission tomography (PET) radioligands to assess...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Rook, Jerri M, Tantawy, Mohammed N, Ansari, Mohammad S, Felts, Andrew S, Stauffer, Shaun R, Emmitte, Kyle A, Kessler, Robert M, Niswender, Colleen M, Daniels, J Scott, Jones, Carrie K, Lindsley, Craig W, Conn, P Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289965/
https://ncbi.nlm.nih.gov/pubmed/25241804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.245
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