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Genetic interaction analysis of point mutations enables interrogation of gene function at a residue-level resolution: Exploring the applications of high-resolution genetic interaction mapping of point mutations

We have achieved a residue-level resolution of genetic interaction mapping – a technique that measures how the function of one gene is affected by the alteration of a second gene – by analyzing point mutations. Here, we describe how to interpret point mutant genetic interactions, and outline key app...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Bioessays
Päätekijät: Braberg, Hannes, Moehle, Erica A., Shales, Michael, Guthrie, Christine, Krogan, Nevan J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289610/
https://ncbi.nlm.nih.gov/pubmed/24842270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201400044
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