Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

BACKGROUND: Functional disturbances of the endoplasmic reticulum (ER) lead to activation of the unfolded protein response (UPR), which is involved in the consecutive steps of carcinogenesis. In human hepatocellular carcinoma (HCC), the UPR is shown to be activated; however, little is known about the...

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Publicat a:Hepatol Int
Autors principals: Vandewynckel, Yves-Paul, Laukens, Debby, Bogaerts, Eliene, Paridaens, Annelies, Van den Bussche, Anja, Verhelst, Xavier, Van Steenkiste, Christophe, Descamps, Benedicte, Vanhove, Chris, Libbrecht, Louis, De Rycke, Riet, Lambrecht, Bart N., Geerts, Anja, Janssens, Sophie, Van Vlierberghe, Hans
Format: Artigo
Idioma:Inglês
Publicat: Springer India 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289530/
https://ncbi.nlm.nih.gov/pubmed/25598862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12072-014-9582-0
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