Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

BACKGROUND: Functional disturbances of the endoplasmic reticulum (ER) lead to activation of the unfolded protein response (UPR), which is involved in the consecutive steps of carcinogenesis. In human hepatocellular carcinoma (HCC), the UPR is shown to be activated; however, little is known about the...

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Detalhes bibliográficos
Publicado no:Hepatol Int
Main Authors: Vandewynckel, Yves-Paul, Laukens, Debby, Bogaerts, Eliene, Paridaens, Annelies, Van den Bussche, Anja, Verhelst, Xavier, Van Steenkiste, Christophe, Descamps, Benedicte, Vanhove, Chris, Libbrecht, Louis, De Rycke, Riet, Lambrecht, Bart N., Geerts, Anja, Janssens, Sophie, Van Vlierberghe, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Springer India 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289530/
https://ncbi.nlm.nih.gov/pubmed/25598862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12072-014-9582-0
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