Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

BACKGROUND: Functional disturbances of the endoplasmic reticulum (ER) lead to activation of the unfolded protein response (UPR), which is involved in the consecutive steps of carcinogenesis. In human hepatocellular carcinoma (HCC), the UPR is shown to be activated; however, little is known about the...

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Enregistré dans:
Détails bibliographiques
Publié dans:Hepatol Int
Auteurs principaux: Vandewynckel, Yves-Paul, Laukens, Debby, Bogaerts, Eliene, Paridaens, Annelies, Van den Bussche, Anja, Verhelst, Xavier, Van Steenkiste, Christophe, Descamps, Benedicte, Vanhove, Chris, Libbrecht, Louis, De Rycke, Riet, Lambrecht, Bart N., Geerts, Anja, Janssens, Sophie, Van Vlierberghe, Hans
Format: Artigo
Langue:Inglês
Publié: Springer India 2014
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289530/
https://ncbi.nlm.nih.gov/pubmed/25598862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12072-014-9582-0
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