Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. We previously showed that the inhibition of placental growth factor (PlGF) exerts antitumour effects and induces vessel normalisation, possibly reducing hypoxia. However, the exact mechanism underlying these e...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Vandewynckel, Yves-Paul, Laukens, Debby, Devisscher, Lindsey, Bogaerts, Eliene, Paridaens, Annelies, Van den Bussche, Anja, Raevens, Sarah, Verhelst, Xavier, Van Steenkiste, Christophe, Jonckx, Bart, Libbrecht, Louis, Geerts, Anja, Carmeliet, Peter, Van Vlierberghe, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707726/
https://ncbi.nlm.nih.gov/pubmed/26753564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1990-6
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