Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis

The role of endoplasmic reticulum stress and the unfolded protein response (UPR) in cholestatic liver disease and fibrosis is not fully unraveled. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been shown to reduce endoplasmic reticulum (ER) stress and counteract apoptosis in differ...

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Xehetasun bibliografikoak
Argitaratua izan da:Int J Mol Sci
Egile Nagusiak: Paridaens, Annelies, Raevens, Sarah, Devisscher, Lindsey, Bogaerts, Eliene, Verhelst, Xavier, Hoorens, Anne, van Vlierberghe, Hans, Van Grunsven, Leo A., Geerts, Anja, Colle, Isabelle
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297843/
https://ncbi.nlm.nih.gov/pubmed/28117681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18010214
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