Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis

The role of endoplasmic reticulum stress and the unfolded protein response (UPR) in cholestatic liver disease and fibrosis is not fully unraveled. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been shown to reduce endoplasmic reticulum (ER) stress and counteract apoptosis in differ...

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Detaylı Bibliyografya
Yayımlandı:Int J Mol Sci
Asıl Yazarlar: Paridaens, Annelies, Raevens, Sarah, Devisscher, Lindsey, Bogaerts, Eliene, Verhelst, Xavier, Hoorens, Anne, van Vlierberghe, Hans, Van Grunsven, Leo A., Geerts, Anja, Colle, Isabelle
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297843/
https://ncbi.nlm.nih.gov/pubmed/28117681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18010214
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