Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis

The role of endoplasmic reticulum stress and the unfolded protein response (UPR) in cholestatic liver disease and fibrosis is not fully unraveled. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been shown to reduce endoplasmic reticulum (ER) stress and counteract apoptosis in differ...

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Pubblicato in:Int J Mol Sci
Autori principali: Paridaens, Annelies, Raevens, Sarah, Devisscher, Lindsey, Bogaerts, Eliene, Verhelst, Xavier, Hoorens, Anne, van Vlierberghe, Hans, Van Grunsven, Leo A., Geerts, Anja, Colle, Isabelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297843/
https://ncbi.nlm.nih.gov/pubmed/28117681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18010214
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