Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis

The role of endoplasmic reticulum stress and the unfolded protein response (UPR) in cholestatic liver disease and fibrosis is not fully unraveled. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been shown to reduce endoplasmic reticulum (ER) stress and counteract apoptosis in differ...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Paridaens, Annelies, Raevens, Sarah, Devisscher, Lindsey, Bogaerts, Eliene, Verhelst, Xavier, Hoorens, Anne, van Vlierberghe, Hans, Van Grunsven, Leo A., Geerts, Anja, Colle, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297843/
https://ncbi.nlm.nih.gov/pubmed/28117681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18010214
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