Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis

The role of endoplasmic reticulum stress and the unfolded protein response (UPR) in cholestatic liver disease and fibrosis is not fully unraveled. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been shown to reduce endoplasmic reticulum (ER) stress and counteract apoptosis in differ...

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Опубликовано в: :Int J Mol Sci
Главные авторы: Paridaens, Annelies, Raevens, Sarah, Devisscher, Lindsey, Bogaerts, Eliene, Verhelst, Xavier, Hoorens, Anne, van Vlierberghe, Hans, Van Grunsven, Leo A., Geerts, Anja, Colle, Isabelle
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297843/
https://ncbi.nlm.nih.gov/pubmed/28117681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18010214
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