Effect of prolyl hydroxylase domain 2 haplodeficiency on liver progenitor cell characteristics in early mouse hepatocarcinogenesis

Activation of the hypoxia-inducible factor (HIF)-pathway in hepatocellular carcinoma (HCC) induces therapy resistant tumours, characterized by increased liver progenitor cell (LPCs) characteristics and poor prognosis. We previously reported corresponding results in mice with HCC in which hypoxia was...

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Detalhes bibliográficos
Publicado no:EXCLI J
Main Authors: Bogaerts, Eliene, Paridaens, Annelies, Verhelst, Xavier, Carmeliet, Peter, Geerts, Anja, Van Vlierberghe, Hans, Devisscher, Lindsey
Formato: Artigo
Idioma:Inglês
Publicado em: Leibniz Research Centre for Working Environment and Human Factors 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318796/
https://ncbi.nlm.nih.gov/pubmed/28337100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2016-607
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