Effect of prolyl hydroxylase domain 2 haplodeficiency on liver progenitor cell characteristics in early mouse hepatocarcinogenesis

Activation of the hypoxia-inducible factor (HIF)-pathway in hepatocellular carcinoma (HCC) induces therapy resistant tumours, characterized by increased liver progenitor cell (LPCs) characteristics and poor prognosis. We previously reported corresponding results in mice with HCC in which hypoxia was...

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Publicat a:EXCLI J
Autors principals: Bogaerts, Eliene, Paridaens, Annelies, Verhelst, Xavier, Carmeliet, Peter, Geerts, Anja, Van Vlierberghe, Hans, Devisscher, Lindsey
Format: Artigo
Idioma:Inglês
Publicat: Leibniz Research Centre for Working Environment and Human Factors 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318796/
https://ncbi.nlm.nih.gov/pubmed/28337100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2016-607
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